Sulphates, phosphates and heavy metals such as lead, cadmium and ferrous are considered as a serious environmental pollutant due to their ability to persistent within the environment and therefore case a serious damage to various ecosystem components.  This study aimed to develop and assess the integration models between biomonitoring process in form of oxidative stress components and a Geographic Information System (GIS), to evaluate the pollutants exposure and their effects on surrounding biomonitoring agent Crocothemis erthrea with respect to using a control study area . The biomonitoring processes were done using colorimetric analysis in form of oxidative stress parameters (including the activity of glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione-s-transferase (GST)) in brain, thoracic muscles, and gut of male and female C. erthrea collected from different studied areas.  The results showed that the activity of GR was increased in female than male and the increasing levels occurred along decreasing the distance from pollution source in male and female insects. However, there were a fluctuation in the activity of GPx in male insects, and GST in male and female insect along increasing the distance from pollution source with the highest value of 3x-fold and 4x fold, respectively, with respect to control. Our study demonstrated the ability of to combine the biomonitoring-GIS modeling to assess the environmental pollutants and predict the deleterious effect of these pollutants on living organisms inform of oxidative stress issues.