The field experiment was conducted at the Orabi Association Farms, a private farm in El-Kaluobia Governorate, Egypt, during the two consecutive winter seasons of 2022/2023 and 2023/2024 to assess the effects of the foliar application of potassium silicate and calcium nitrate, whether in Nano form or mineral fertilizers form on the growth, yield, and quality characteristics of potato (Hermes cv.). Six treatments were applied in the field experiment: potassium silicate Nano fertilizer at 100 and 1000 ppm, potassium silicate at 2000 ppm, calcium nitrate mineral fertilizer at 2000 ppm, and calcium nitrate Nano fertilizer at 1000 ppm. Based on the results, the Nano potassium silicate treatment at 100 ppm significantly improved the vegetative growth (plant length, number of main shoots, fresh and dry weight and chlorophyll content), total and marketable yield, quality of tubers and silicon and potassium contents of leaves. The study demonstrated that application of Nano fertilizers is recommended since they are low-cost and safe for environmental.