The natural resources of agricultural lands in Egypt are exposed to many problems due to the application of improper management as well as climatic changes. The exogenous application of Glycine betaine (GB) and proline is a convenient method for the induction of crop tolerance to various abiotic stresses.Olinda Valencia orange trees (Citrus sinensis) (C.sinensis L.) budded on Volkamer lemon rootstock (Citrus Volkameriana) Tan. andPasq. were grown in soil influenced by salinity (where EC was 3.64 ds/m) at El Bustan County, El Behera Governorate, Egypt were used under study. Trees were sprayed with proline and (GB) twice (at full bloom stage and two weeks later) during the two seasons (2020 and 2021). The experiment included seven treatments as follow: proline at (100, 200 and 300 ppm), Glycine betaine (GB) at (1000, 2000 and 3000 ppm), and untreated trees (salt stress). Results indicated that, exogenous application of proline at 300ppm and (GB) at 2000ppm increased the trees tolerance to the adverse effects of salinity and achieved  the best results (increased the concentrations of leaf total chlorophyll, leaf mineral content) especially the ratio between K⁺ and Na⁺ (where, lower Na⁺ is a good indicator of salt tolerance in plants), improved fruit quality and consequently increased the averages of yield for the two seasons  than the control by 33.4% and 30.6%, respectively .Based on the economic study, it can be recommended to use proline at a rate of 300 ppm to give the highest net profit/fed. (6986 L.E), followed by GB at 2000 ppm (5720 L.E) in descending order, where these treatments mitigated the inhibitory effects of salinity and promoted plant growth, as well as increasing the yield of the final crop.