Background: Among patients suffering from end-stage liver disease, liver transplantation (LT) is the therapy of choice; nonetheless, post -liver transplantation fatigue is a significant concern, and its prevalence didn't decline in the two years following surgery. Even though hyperlipidemia is prevalent following liver transplantation (affecting as many as 71% of patients). Purpose: To assess the combinational effect of aerobic and strength exercises on fatigue and lipid profile post–liver transplantation. Materials and Methods: the study design was a pre–test post–test design. Subjects who participated in this study were 40 patients (31 males,9 female) who had liver transplantation for ≤ 1 year of transplantation and Their ages ranged from 20 to 65. Interventions received by patients were aerobic exercises in the form of (a cycle ergometer) for 30 minutes in addition to a strength exercises program for large muscle groups such as (quadriceps femoris, biceps brachii, gluteus maximus, as well as abdominal muscles) for another 30 minutes for 12 consecutive weeks, patients also received traditional medical treatment. The Outcome measures of study were functional capacity, fatigue severity, and lipid profile which were measured pre-treatment and 12-week post-treatment by 6MWT, (Fatigue Severity Scale, and Visual Analogue Scale), and blood analysis respectively. Results: The 6MWT distance increased significantly, the FSS and VAS scores decreased significantly, and the levels of total cholesterol, triglycerides, and LDL decreased significantly (P=0.001). In contrast, the HDL level increased significantly (p=0.007) and the percent of change for each was 24.80%, 41.72%, as well as 15.77%, respectively, after treatment in comparison with before treatment. Conclusion: Combinational application of aerobic and strength exercises had a positive effect on fatigue and hyperlipidemia post-liver.