Bee venom has been used in treatment of many inflammatory diseases, some autoimmune diseases and bovine mastitis. There are some commercially available drugs prepared from bee venom that are used for medical purposes. Abevac is one of these bee venom drugs. The present study show the effect of Abevac against some reference strains of pathogenic Gram-positive bacteria (S.aureus, MRSA, B.cereus and S.pyogenes) usingdisc diffusion method and micro dilution assay against standard antibiotic (penicillin).Abevac is more potent than penicillin on Gram-positive bacteria.