The vaccination campaign (using life Smithburn vaccine) performed during the outbreaks of 1996,1997 and 2003 did not stop the disease but it causes viremia in vaccinated animals which explain the fear of spread of the virus via mosquito's vectors and the concern about possible reasserting event with wild type viruses. The Egyptian GOVS in the 2008
demonstrated that (Rift Valley Fever) live vaccine (Smithburn strain) isn't used in Arab Repuplic of Egypt in the present time. Consequently, the RVF vaccination programs in Egypt are performed by inactivated (ZH-501) RVF vaccine. In this study Inactivated smithburn RVF vaccine was prepared and evaluated by serological tests (SNT and ELISA), compared with
local vaccine. Results indicated that Smithburn RVF vaccine was more protective, induced high titer of antibodies. Furthermore, time of protection is longer than the local vaccine.