A total number of 43 patient dogs of different ages, sexes and breeds involved in this study. The present search was designed to study some epidemiological aspects of canine pyoderma, clinical and bacteriological parameters in dogs. High prevalence level was recorded in German shepherd dogs (32.55%). Main clinical signs observed among examined (43) dogs
were pruritus, erythema, alopecia disperse with easy hair epilating, papulo-pustular eruptions, erosive or ulcerative lesions, scaling, crusting. Other clinical signs such as otitis, foul smelling odor, anal sacculitis, draining tracts and deep wounds, cutaneous swellings and thickening of the footpads (pododermatitis) were also recorded. Bacteriological examination (isolation, identification and culture sensitivity testing) revealed Staphylococcus aureus was the most predominant microorganism isolated from the affected dogs (27 cases, 62.8%), Staph. intermedius (9 cases, 21%), Gram positive catalase +ve (one case, 2.2%) and Gram-ve bacteria (6 cases, 14%). A total number of 43 isolate (37 G+ve isolates and 6 Gram -ve isolates). Pyoderma due to Gram positive was sensitive to Amoxicillin+ clavulanic acid (43.2%) while the Gram negative was sensitive to Neomycin (50%).