Twenty buffalo male calves, weighted 200.5±8.8Kg and 12.5±0.3 months of age used to investigate the ameliorative effect of dietary selenium and yeast culture supplementation on growth performance, some blood metabolic profile and examine potency for the removal blood efficiency of lead (Pb) and cadmium (Cd). Calves were selected and divided randomly
into 4 similar groups (5 animals each) throughout the fattening period (6 month). All calves in the different groups were fed similar basal diet of concentrate feed mixture (CFM), ad libitum berseem hay (BH) and rice straw (RS). First group (G1, control) fed the basal diet without additive. G2 group fed the basal ration supplemented with 15g/head/day yeast culture
Saccharomyces cerevisiae (from Megabest).While, G3 group fed the basal ration supplemented with 0.3 ppm selenium (Se) as aqueous solutions of sodium selenite, and G4 group fed basal ration with 0.3 ppm Se+15g/head/day yeast culture. Calves were naturally exposed to environmental lead (Pb) and cadmium (Cd) in Mahlet-Mosa farm in Kafr El-Sheikh governorate, Lead and cadmium concentration was 1.94+0.512 and 0.46+0.059ppm in drinking water and 0.92+0.210 and 0.37+0.068 mg/kg DM in feed, respectively. Serum Se concentration was affected by feed yeast and Se supplementation (p<0.05) which Increased in G4 and G3 supplemented groups. G4 and G2 yeast supplemented groups significantly increased (P<0.05) in average daily body weight gain (ADG), Relative growth rate and feed conversion as DMI/kg gain and improved with no significant effect in average DMI (kg/100 kg BW) for G4 and G2 groups were higher gain by 22.24 and 14.96% and marginally low in G3 by 2.54% than the control group. Serum Se levels and globulin concentration were affected by supplementation Se (p<0.05) which Increased in G4 and G3 supplementation groups. However, the highest value
of serum albumin and A: G ratio were significantly (P<0.05) observed with yeast culture supplemented (G3).The plasma status of lead was decreased significantly by supplementation of Se and Se+yeast (G3 and G4) treatments, whereas calves fed yeast as supplemented (G2) had no effect on plasma lead but affected significantly cadmium concentrate. There was no
significant effect on Hb and PCV in supplemented groups, the control group tented to be decrease than treatment groups. Blood components of total protein, glucose, urea, creatinine, uric acid, ALT, AST, thyroid hormone blood activities of T3, T4, and T4:T3 ratio in blood calves in serum had no significant effect by supplementation of Se (G3) and/or yeast culture
(G2) throughout the experimental period, G2 supplementation group was the highest values of total protein levels but control group calves had the highest activity levels the most examined enzymes on concentration blood buffalo calves comparable among four buffalo calves groups throughout the experimental period