Ticks and fleas are considered the most common external parasites infesting dogs. Total of (117) dogs were examined for external parasitic infestation; ticks and fleas were collected and subjected for identification. Fecal samples also collected and examined for presence of any internal parasites. Ticks were identified as R. sanguineus and fleas as C. felis. Epidemiological data (age, sex, breed and season) were recorded. Clinical signs were reported in form of emaciation, anemia, pale mucous membrane, itching, pruritus and alopecia. In vitro and in vivo studies were conducted on parasidose shampoo as a natural therapeutic product for control of ticks and fleas with active ingredient Biococidine. It was proved that parasidose effective on both of them and this was the first data recorded from Egypt. Natural oils were used and evaluated as repellent for these external parasites.