PGE is a principal cause of losses in sheep manufacture. The present study aimed to assess oxidative stress and serum biochemical status in sheep with PGE. Fifteen adult sheep infested with PGE and seven control adult sheep were involved in this study, clinical signs and fecal examination findings were recorded, as well blood samples were taken to investigate serum biochemical variations and oxidative stress biomarkers status. The most consistent clinical signs recorded in affected sheep include weight loss, diarrhea, and anemia with pale conjunctival mucous membranes and generalized weakness. Significant increase in Hydrogen peroxide activity along with significant decrease in total antioxidant capacity and Catalase
activities was detected in diseased group. Significant decrease in total protein, albumin, Zinc and iron was observed in diseased group. In the current investigation, oxidant/antioxidant imbalance along with the alterations in biochemical findings was detected in sheep with parasitic (GE). These findings support that PGE associated with oxidative stress and this
procedure may be related to the resulting clinical signs.