Camelpox and rabies are important zoonotic viral diseases with public health hazard in addition to its great economic lose. Vaccinations with pox lead to nonspecific paramunity in a wide variety of animals; the present work investigates the effect of mutual vaccination of camels with rabies and camel pox vaccines on their immune response. Such investigation was carried out through vaccination of camel groups with single rabies and camel pox vaccines; administration of camel pox vaccine 2 weeks before vaccination with rabies vaccine in another camel group while simultaneous vaccination with the 2 vaccines was applied on another camel group. Cellular and humeral immune responses of such camels were evaluated using lymphocyte plastogenesis assay (LPA) and serum neutralization test (SNT) respectively. The obtained results indicated the possibility of camel vaccination with rabies and camel pox vaccines in singly or simultaneous manner where there was no antagonizing effect between them on the vaccinated camel's immune response. However there was clear rise in the levels
of rabies antibodies in case of administration of camel pox before or simultaneously with rabies vaccine reflecting the immune modulatory effect of camel pox to rabies vaccine.