Vibrios are a group of Gram-negative septicemic bacteria that mainly affect marine, estuarine fishes and freshwater fishes sometimes. Vibrios are ubiquitous in open water resources especially seawater and estuarine habitats. In the current study, four main species of Vibrios were commonly isolated/identified from the thin lip grey mullet (Liza ramada) collected
through spring 2017 to autumn 2017. The identities of the retrieved isolates were confirmed as Vibrio alginolyticus (V. alginolyticus), Vibrio fluvialis (V. fluvialis) Vibrio Parahaemolyticus(V. Parahaemolyticus) and Vibrio vulnificus (V. vulnificus) depending on their morphological /biochemical characteristics obtained from the adopted conventional and semi-automated biochemical tests (API20E). All isolates characters were in full accordance with the standard criteria stated by the Bergey's Manual of Systemic Bacteriology. Results has also revealed that V. alginolyticus was the highest isolated species (27.50 %) in Summer 2017 and autumn 2017(22.50%) ,while V. vulnificus was the lowest isolated through spring 2017 (3.75%) and autumn 2017(3.75%) . In spring season 2017, V. parahaemolyticus presented the highest percentage of infection (12.5 %). Antibiogram has revealed that most of the retrieved V. alginolyticus were sensitive to Doxycycline and Polymyxin and resistant to oxytetracyclin, florfenicol and Ampicillin. However V. fluvialis isolate were sensitive to all tested antibiotics with the exception of Ampicillin. From environmental point of view, the achieved results are indicative of consistently uprising agricultural /municipal drainage pollution across the northern delta provinces (lakes). Further, the occurrence of certain degrees of antibiotic resistances is also supporting the assumption that. the main source of antibiotics in the open water is the dumping of agricultural / municipal drainage. Ultimately, screening of the antibiotic resistance genes is highly required in the future.