The current study was carried out to investigate the role of unpredictable chronic mild stress as a model of depression on the physical and behavioral parameters of male Swiss mice. Twenty- Five adult male Swiss albino mice were housed in either control group or unpredictable chronic mild stress (UCMS) group that was exposed to different physical stressors for 8 weeks. Body weight and body coat were assessed. Sucrose consumption test, reward maze test, elevated plus maze and forced swim test were conducted. UCMS mice displayed a reduction in body weight, and decreased sucrose consumption, while exhibited an increase in the latency to pass 1st gate of the reward maze. UCMS mice also showed a tendency of being in the closed arm of the elevated plus maze for a longer duration compared to mice in the control group, a tendency of being immobile in forced swim test. In conclusion, physical changes in conjunction with the significant behavioral changes strongly support the efficacy of UCMS as a model of depression in the human being.