A feeding trial was conducted to evaluate the effect of live yeast cells (Saccharomyces cerevisiae) on the growth performance of beef buffalo calves. The experiment was performed on 45 intact (non-castrated) male buffalo calves of (246.8±7.1 kg and 8to 9 months). They were randomly divided to three equal groups of 15 animals each. The control group was fed ration without live yeast cells (CD = control diet), 2nd experimental group was fed ration fortified with 0.5g/day of live yeast cells in the diet (YC0.5) and 3rd experimental group was fed ration with 1 g/day of live yeast cells in the diet (YC1). During the trial, calves in all groups were offered a conventional concentrate mixture to meet the protein requirements for
maintenance and growth. Feeding of all animals carried out by TMR according to their planned ration requirement that calculated for animal based on that for cattle in the same size and weight. The beef buffalo calves were fed on ration supplemented with Saccharomyces cerevisiae (YC 0.5) (YC 1) showed a significant (P <0.05) improvement in final body weight and weight gain with no significant difference in DMI compared to control group. The average daily gains (ADG) were significantly increased (P<0.05) in (YC 1) compared to control group. The FCR for buffalo calves in (control, YC0.5 and YC 1) groups were (8.94 ±0.96, 8.31 ±0.6 and 7.82±0.55) respectively. The cost of feed /kg gain for buffalo calves in the (control, YC0.5and YC 1) were calculated as (42.2, 37.5 and 36.9) £ respectively. It was concluded that inclusion of yeast culture (Saccharomyce scerevisiae CNCM I-1077 strain) has a positive effect on final body weight, body weight gain and FCR with decreasing the cost of feed per unit live weight gain in buffalo bull calves without any adverse effects.