This study was designed to evaluate the effect of Moringa oleifera (MO) tree leaves supplementation on growth and reproductive performance of growing ewes in Egypt. Twelve ewes with average initial weight 25.57 ± 4 .62 kg were randomly divided into two groups (6 females each). Group 1 served as the control group, and these animals only feed
without any supplementation. In addition to the natural pasture, Group 2 received 10 g of M. oleifera dried leaf meal. For 45 day the animals in both groups subjected to close observation for 6 months to compared between the control and supplemented group,WBC, lymphocytes, monocytes, neutrophils, total protein, globulin,total antioxidants, progesterone,
palmitic, oleic, linoleic acid was differed (P<0.05) significantly in the supplemented group than the control one. Also, the overall body weight gain and the final body weight of the ewes were significantly differed between two groups. All reproductive efficiency parameters measured such as birth rate, twinning rate were significantly (p< 0.05) higher in supplemented ewes compared to the control. Body weights at birth of the offspring in supplemented ewes
were, however, significantly (p>0.05) affected by supplementation. We concluded that the Moringa oleifera tree leaves can be used as supplementation to improve the growth and reproductive performance with no harmful effects on their health.