The present work was aimed to isolate and clarify the pathogenesis of Trueperella pyogenes (T. pyogenes) in pregnant she camels particularly its effect on the reproductive performance causing abortion. Pathological data available in the current literature regarding pyometra in dromedary camels due to T. pyogenes infection.196 blood, nasal swab and tissue samples
were collected aseptically from 176 she-camels for bacterial culture, serological identification and study the histopathological alterations and fluorescent technique. The samples were collected from dromedary she camels in three Egyptian governorates (Mattrouh, El-Sharkia and Giza). The bacteriological examinations revealed that T. pyogenes which isolated by percentage of (13.27%) were mainly responsible for the abortion. The experimental infection with the isolated bacterial strain were applied on pregnant New Zealand rabbit does to compare and confirm that, the abortion resulted in she camels were due to the natural infection with T. pyogenes. Antibiogram pattern was applied and the most effective drugs
against the pathogen were Amoxicillin/clavulanic acid (100%), Cefotaxime (96.2%), Ampicillin (92.3%), and Ciprofloxacin (80.8%). The histopathological examination of the uterus and placenta of the aborted she camels revealed purulent endometritis and placentitis. Necrosis of hepatic tissues and interstitial bronchopneumonia with suppuration in the lung
and intestine of aborted foeti were observed. Nearly similar lesions in the experimentally infected does were evident