Background and aim, metabolic associated fatty liver disease (MAFLD) is a new definition in 2020. MAFLD is extremely away concept from criteria for non-alcoholic fatty liver disease (NAFLD). The most significant differences between MAFLD and NAFLD are diagnosis of MAFLD not need alcohol exclusion, chronic liver diseases and the existence of metabolic dysregulation is substantial for MAFLD diagnosis. The current study aimed to distinguish risk factors of MAFLD in Fayoum Governorate. Subjects and methods, in total 1061 subjects of simple random samples from Fayoum University Hospital were selected to perform the current cross-sectional study. The selected subjects were clinically assessed and investigated by laboratory tests including Liver enzymes, serum lipid profile, and imaging i.e., abdominal ultrasound and transient elastography (fibroscan). Results, level of blood cholesterol and triglycerides were a statistically significantly higher in patients with MAFLD than those without MAFLD. Multiple forward stepwise logistic regression analysis identified female sex. High cholesterol level, and high triglycerides level to be statistically significant predictors for MAFLD. Conclusion, according to our research, patients with MAFLD had a statistically significant higher BMI than those without MAFLD. Blood triglyceride and cholesterol levels were statistically substantially higher in MAFLD patients than in non-MAFLD individuals. High numbers of individuals with MAFLD were diabetics and hypertensives.