Five cultivars of bread wheat (Triticum aestivum L.) were used in this study at Fayoum University, Fayoum Governorate, during 2019/2020 and 2020/2021 growing seasons. The objective of the study was to assess the yield of newly developed bread wheat cultivars under conditions of water stress (drought indices). The experiment consisted of two factors, which were three different water stress conditions and five different wheat cultivars. The results showed that skipping irrigations had a significant effect on grain yield, with the highest reduction of 42.9% observed when irrigations at the heading stage were skipped compared to full irrigation. The variety Sakha-95, Misr-3, exhibits a higher level of drought tolerance during the elongation and flowering stages. Stress susceptibility index (SSI) under drought stress conditions (skipping irrigation during the elongation stage (I2) and skipping irrigation during heading stages (I3)), the Sakha-95 performed better in the two irrigation skips on grain yield. Misr-3," followed by Sakha-95," are the top-performing varieties in the yield index (YI) of drought tolerance during the flowering stages. Also, the Sakha-95" variety showed the highest stress tolerance index (STI) value of 1.08 when irrigation skips at the heading stage. While the variety "Sids-14" displayed the highest STI value (1.04), only irrigation at the elongation stage was skipped.