The prevalence of mental health problems among university-going students exponentially rose during the last few years in India. Psychological distress among college-going students has been reported in many studies. Mental health problems such as depression, anxiety, stress, addictions, and risk for suicide have been reported. However, there is no scoping and systematic review quantified with reviewing overall psychiatric state of mind among students in India. The purpose of this scoping and systematic review was to identify the psychiatric state of mind among college-going students in India. The investigator searched major databases such as Google Scholar, PubMed, PsycINFO, Scopus, and ISI Proceeding articles from the year of 2012 to August 2022 and conducted a detailed review based on the selection criteria. The results revealed that the majority of the studies included in the review were descriptive and mainly studied depression, anxiety disorders, stress, suicidal thoughts, and substance use disorders among undergraduate university students. Significant predictors of mental distress among college students included academic stress, lack of social support, and current drug use. This review suggests that university students may encounter a variety of mental disorders that affect their academic performance. The limited evidence does not allow conclusions to be drawn. Further multicentric research is required in India to quantify psychiatric state of mind. So, collaborative, multidimensional, and culturally sensitive preventive mental health programs can be developed for the students to promote their psychosocial well-being and improve their overall quality of life.