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314420

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

Article

Last updated: 29 Dec 2024

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Abstract

Purpose: We conducted a systematic review and network meta-analysis (NMA) to estimate the efficacy of Helicobacter pylori (H. pylori) treatment strategies in Arab countries.
Methods: We searched electronic databases from inception to July 18, 2020, using boolean operators. Search terms were (Helicobacter pylori R H. pylori OR pylori OR helicobacter). The risk of bias was assessed using Cochrane risk of bias tool. Retrieved articles were screened, and relevant data were extracted. We used R programming software to analyze extracted data.
Results: Fifty-four articles (n= 7829 patients) were included in the NMA. Pooled analysis demonstrated that adjuvant therapy (standard triple or sequential therapy plus another adjuvant drug) was the best treatment with higher odds of eradication rate [OR= 6.42, 95% CI (1.37: 30.05), P-score= 0.21]. In naïve population, quinolones-based therapy (QBT) and sequential therapy (SQT) were associated with higher eradication rates than other regimens [OR= 1.94, 95% CI (1.19: 3.16), P score=0.19] and [OR= 1.66, 95% CI (1.10: 2.50), P score=0.33]. In experienced population, all medication showed a non-significant difference in eradication rates when compared to triple therapy (TT); QBT (OR= 1.86, 95% CI, [0.15, 22.88], p=0.44) and SQT (OR= 1.49, 95% CI, [0.13, 17.59], p=0.52).
Conclusion: Our findings suggested that QBT and SQT therapies were the most effective regimens for eradicating H. pylori in naïve patients in the Arab countries. In experienced patients, all medication showed a non-significant difference in eradication rates.

DOI

10.21608/gg.2023.203591.1010

Keywords

eradication, Anti-Bacterial Agents, Quinolones, bismuth, resistance

Authors

First Name

Shimaa

Last Name

Afify

MiddleName

-

Affiliation

Gastroenterology department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.

Email

drshima202@yahoo.com

City

-

Orcid

0000-0001-5937-4240

First Name

Muhammad

Last Name

Abdel-Gawad

MiddleName

-

Affiliation

Hepatology, Gastroenterology, and Infectious Diseases Department, Al-Azhar University, Assiut, Egypt.

Email

muhammad2013@azhar.edu.eg

City

-

Orcid

0000-0002-0204-4715

First Name

Eshak

Last Name

Bahbah

MiddleName

I.

Affiliation

Faculty of Medicine, Al-Azhar University, Damietta, Egypt.

Email

isaacbahbah@gmail.com

City

-

Orcid

-

First Name

Mariam

Last Name

Zaghloul

MiddleName

-

Affiliation

Gastroenterology and Infectious Diseases department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt

Email

mariam_zaghloul@med.kfs.edu.eg

City

-

Orcid

0000-0002-4244-5396

First Name

Ahmed

Last Name

abu-Elfatth

MiddleName

-

Affiliation

Tropical Medicine and Gastroenterology Department, Assuit University, Assuit Egypt.

Email

ahmed111@aun.edu.eg

City

-

Orcid

0000-0003-3269-5284

First Name

Ahmed

Last Name

Alzamzamy

MiddleName

-

Affiliation

Department of Gastroenterology and Heptology, Maadi Armed Forces Medical Complex, Military Medical Academy,

Email

dr_zamzamy@hotmail.com

City

-

Orcid

0000-0002-3817-5370

First Name

Gina Gamal

Last Name

Nagui

MiddleName

-

Affiliation

Department of internal medicine, Ain shams university, Cairo, Egypt

Email

gina_gamal@med.asu.edu.eg

City

Cairo

Orcid

0000-0001-9336-4329

First Name

Doaa

Last Name

Elwazzan

MiddleName

-

Affiliation

Tropical Medicine Department, Alexandria Faculty of Medicine, Alexandria, Egypt

Email

doaa.elwazzan@alexmed.edu.eg

City

-

Orcid

0000-0002-4242-6232

First Name

Nermeen

Last Name

Abdeen

MiddleName

-

Affiliation

Alexandria UniversityTropical Medicine Department, Alexandria Faculty of Medicine, Alexandria, Egypt

Email

-

City

Alexandria

Orcid

-

First Name

Mina

Last Name

Tharwat

MiddleName

-

Affiliation

Tropical medicine and Gastroenterology, Aswan University, Aswan, Egypt

Email

minatharwat_tropical@yahoo.com

City

Aswan

Orcid

0000-0001-9834-1644

First Name

Osama

Last Name

Elbahr

MiddleName

-

Affiliation

Hepatology and gastroenterology department National liver Institute Menofia university

Email

osama.elbahr@liver.menofia.edu.eg

City

-

Orcid

0000-0001-6902-8982

First Name

Iliass

Last Name

Charif

MiddleName

-

Affiliation

Department of hepatology and gastroenterology Al Farabi Hospital. Oujda. Morocco

Email

iliass82@yahoo.fr

City

-

Orcid

-

First Name

Galal

Last Name

Aboufarrag

MiddleName

-

Affiliation

Hepatology, gastroenterology and infectious diseases Department, Al-Azhar University, Cairo, Egypt.

Email

drgalal2009@yahoo.com

City

-

Orcid

0000-0003-3929-2795

First Name

Mohamed

Last Name

Elbadry

MiddleName

-

Affiliation

Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.

Email

melbadry2002@yahoo.com

City

-

Orcid

0000-0002-9020-8870

First Name

Dalia

Last Name

Omran

MiddleName

-

Affiliation

Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

daliaomran@kasralainy.edu.eg

City

-

Orcid

-

First Name

Sherif

Last Name

Abd-Elsalam

MiddleName

-

Affiliation

Tropical Medicine and Infectious diseases Department, Tanta University, Tanta, Egypt

Email

sherif.abdelbaky@med.tanta.edu.eg

City

-

Orcid

0000-0003-4366-2218

First Name

Zainab

Last Name

Ali-Eldin

MiddleName

-

Affiliation

Department of internal medicine, Ain shams university, Cairo, Egypt

Email

zainab_ahmed@med.asu.edu.eg

City

-

Orcid

0000-0001-5157-3149

First Name

Nahed

Last Name

Makhlouf

MiddleName

A.

Affiliation

Tropical Medicine and Gastroenterology Department, Assuit University, Assuit Egypt.

Email

nahedmak@yahoo.com

City

-

Orcid

0000-0003-2949-4369

First Name

Mohamed

Last Name

Alboraie

MiddleName

-

Affiliation

Department of internal medicine, Al-Azhar University, Cairo 11884, Egypt.

Email

alboraie@azhar.edu.eg

City

Cairo

Orcid

0000-0002-8490-9822

Volume

1

Article Issue

1

Related Issue

43113

Issue Date

2023-08-01

Receive Date

2023-04-02

Publish Date

2023-08-01

Print ISSN

2974-4245

Online ISSN

2974-4253

Article File

GG3144201690837200.pdf

PDF . 963.3kB

Link

https://gg.journals.ekb.eg/article_314420.html

Detail API

https://gg.journals.ekb.eg/service?article_code=314420

Order

314,420

Type

Meta-analyses and research proposals which bring new innovations to the field of gastroenterology.

Type Code

2,695

Publication Type

Journal

Publication Title

Global Gastroenterology

Publication Link

https://gg.journals.ekb.eg/

MainTitle

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

Details

Type

Article

Created At

18 Dec 2024