Shoulder disorders increased between some workers especially if their jobs require combinations of exposure to overhead, heavy loads, vibrations, forceful work, and repetitions of these activities. The purpose of this study is to manage patients with shoulder impingement syndrome among manual operated hand worker. Thirty six patients participated in the study; they were divided into two equal groups, 18 per each. Group A received TENS, rotator cuff and scapular muscle strengthening exercises for 6 consecutive weeks, 3 times per week. Group B received TENS, scapular muscle, rotator cuff strengthening exercise plus Core stability Training for 6 consecutive weeks, 3 times per week. Visual analogue scale, digital goniometer, PBU and endurance tests for assessment shoulder pain, range of motion, and core stability respectively. All outcome measures were measured before and after intervention program. Pain intensity level showed a significant reduction within groups (P≤0.0001). Between groups, it showed no significant difference between group A versus group B (p=1.000 and 0.486 respectively). Shoulder ROM showed a significant increase within groups (P≤0.0001). Between groups it showed no significant difference between group A versus group B (p=0.844, 0.556 respectively for shoulder flexion; p=0.174 and 0.784 respectively for shoulder abduction; p=0.053 and 0.514 respectively for shoulder scaption; and p=0.200 and 0.150 respectively for shoulder external rotation). Core stability showed no significant in group A for all (P=0.759, 0.731, 0.909, 0.400, and 0.107 respectively) but showed  significant increase in group B for all  (P=0.0001 for all) except SBEET showed no significant difference(P=0.101). Between groups, it showed significant difference within groups with favor for group B than group A(P=0.0001, 0.001, 0.0001, 0.0001, and 0.0001) and (0.221, 0.057, 0.395, 0.262, and 0.057) respectively. Conclusion: Core stability training didn't have an effect on shoulder pain and shoulder ROM in patients with shoulder impingement syndrome among manual operated hand workers.