The study examines out-coming wastewater treatment plant for reuse water as non-conventional water resource in Itsa, El-Fayoum Governorate. The traditional water resources are limited so the study focuses on the quality of treated wastewater for irrigation along treatment plants. Water samples were collected during the period from 2018 to 2019. The water parameters were set using the Egyptian irrigation water standards. The results of the study clearly demonstrate restrictions to irrigate the uncooked vegetables and uncooked crops for human. The need for increasing Nile freshwater portion or pretreatment of the wastewater prior to mixing with the Nile freshwater to satisfy Egyptian irrigation water standards and USEPA 2012 as several water quality results, such as BOD, DO, and fecal coliform, are unacceptable. As a suggestion, we recommend using aerated lagoons, stabilization ponds or wetlands to treat polluted agriculture wastewater before adding to the Nile river water to satisfy Egyptian irrigation water criteria.