The nasal cavity, paranasal sinuses, pharynx, and larynx form a complex upper respiratory tract (URT) system and are susceptible to infections, tumor-like conditions and true neoplastic conditions. The aim of this study is to detect the prevalence of URT lesions, to detect the prevalence of different lesions in different ages and sexes and to detect the etiology and possible high risk factors whenever possible.  A total of 202 specimens of URT lesions were received at the pathology department, Beni-Suef University Hospital during the period from June 2017 to June 2021. All were evaluated histopatholgically. Of which, 59 were also evaluated immunohistochemically using anti-HPV Clone K1H8 antibody.  Nasal polyp was the most prevalent lesion followed by vocal polyp. There was a significant relation of squamous metaplasia with nasal polyps and also there was a significant relation of dysplasia with vocal polyps indicating careful follow up after excision. There was no significant relation between HPV and different lesions with squamous morphology suggesting it as uncertain risk factor.