Background: The leading causes of maternal and neonatal death and morbidity globally continue to be preeclampsia (PE) and eclampsia. Aim of the work: present study was designed to compare histopathological changes, cell to cell adhesion and apoptotic changes in both normotensive and preeclamptic human placenta, using histological, immunohistochemical and morphometric methods. Patients and methods: Sixty pregnant women were included; 30 were normal clinically and considered the control group (group I) and the other 30 were included in the preeclampsia group (group II). Placental tissue was taken from pregnant women aged 25 to 35 who had had a caesarean section in order to end their pregnancy at Obstetric and Gynecology Department, Faculty of medicine, Beni-Suef University Hospital. Sections of placenta were processed and stained with Masson's trichrome, H&E, and immunostained for Bcl-2 and IL-10. Results: Group II (PE) revealed marked elevation in the number of syncytial knots, significant elevation in area percent of collagen fibers, and significant elevation in area percent of IL-10 immunoexpression as compared to group I. But there was marked reduction in the area percent of Bcl-2 immunoexpression. Conclusion: It can be concluded that Preeclampsia is associated with marked inflammatory and immune responses. Bcl-2 and IL-10 are extremely crucial in its pathogenesis. Therefore, they could be possible predictors for PE; in addition, therapeutic agents that can modulate the immune system might hold great promise in its early detection and prevention.