Leukemia represents a kind of malignancy that affects the bone marrow and blood, resulting in un-controlled proliferation of abnormal leucocytes. Cyclophosphamide (CP) chemotherapy has a number of side effects, including liver toxicity and renal toxicity. The goal of the current study was to investigate the potential therapeutic benefits of Camellia sinensis extract (CSE) for treating adult male albino rats with leukemia. Following induction of leukemia with benzene injection, both healthy and leukemic rats were separated into four groups of ten rats each: 1) untreated control rats, 2) induced- leukemia rats, 3) leukemia rats treated orally with (350 mg/kg) daily CSE for 4 weeks, and 4) leukemia rats treated with CP (7.5 mg/kg/48 hr.) for 4 weeks by intra-peritoneal injection. At the conclusion of the experiment, the rats were slaughtered. Hematological markers were assessed, including the complete blood count. The results showed that treating leukemic rats with CSE effectively alleviated the leukemic complication signs, as evidenced by a significant reduction in white blood cells (WBCs) count; additionally, CSE significantly ameliorated histo-pathological alterations in the spleen, restoring normal area percent of collagen fibers, Periodic acid Schiff (PAS)-stained general carbohydrates, and Myeloperoxidase-positive stained splenocytes in a benzene-induced leukemia model. It is possible to conclude that CSE has anti-leukemic potential, making it a promising treatment option for leukemia.