Background: Over 630 million COVID-19 instances have been documented worldwide, and there have been close to 6.5 million fatalities. The primary methods for evaluating the effects of various variables on the COVID-19 mortality rate have centred on individual comorbidities and risk factors related to ageing. Objective: We looked at the connection between COVID-19 degree upon admittance to a quarantined hospital and risk of patient death with an emphasis on several prospective therapies in order to present additional evidences. Patients and methods: 338 participants who were admitted to Ain Shams University Hospitals were the subjects of a retrospective cohort analysis from April 20, 2020, to July 30, 2020, of whom 317 individuals had documented outcomes (hospital discharge or fatal prognosis). Applying logistic regression analysis, it was possible to determine the adjusted hazard variables for fatal outcome. Results: At the univariate stage, individuals who were elderly, smokers, hypertensives, diabetics, and individuals with chronic kidney disease (CKD), as well as those taking steroids, tocilizumab, or enoxaparin sodium, were more likely to have a fatal outcome. Diabetes mellitus (DM) is a strong indicator of death due to its high prevalence (65%) in COVID-19 participants who did not survive. The multivariable investigation suggests only 2 factors from the risk categories significantly related with fatal outcome in the univariate study: older age and steroid use. Conclusion: The use of steroids may be more indicative of the degree of the illness than a terminal prognosis. Steroids are frequently administered to participants who have severe respiratory problems or indications, therefore cause effect bias is extremely possible. Additional research is required to verify the advantages of various drugs in COVID-19 individuals.