Background: Cirrhosis of the liver may be compensated with no obvious complications or decompensated which accompanied by ascites, hematemesis, or renal impairment. Liver disease affects thyroid hormone metabolism, thyroid problems can impair liver functions, and several systemic diseases can affect both organs. Objectives:The aim of the current work was to study level of thyroid hormones in patients with liver cirrhosis and to evaluate the significance of thyroid hormone level and severity of liver cirrhosis. Patients and methods: This case control study included a total of 25 cirrhotic patients and equal number of age and gender matched controls, attending at Hepatology and Gastroenterology unit, Department of Internal Medicine, Faculty of Medicine, Mansoura University. Thyroid hormones were measured and correlated with child Pugh score, model for end-stage liver disease (MELD) score and degree of hepatic encephalopathy (HE). Results: The mean age of the liver cirrhotic patients was54.08±15.14 and for control subjects was 49.32±13.02. There was positive correlation between TSH level, Child score and MELD score (P value <0.001). Also, there was positive correlation between TSH level and degree of hepatic encephalopathy (p value <0.001). Conclusions: Thyroid dysfunction is well established as liver cirrhosis progressed. So, it could be concluded that thyroid levels could be utilized as a prognostic indicator in cirrhotic patients.