Background: Coronavirus disease 2019 (COVID-19) is a pandemic affect the world in end of 2019 which is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading from its origin in Wuhan City of Hubei Province of China to the rest of the world. Objectives: The main objective of this study is to highlight the oro-nasal manifestations that could be reported in mild to moderate cases of COVID-19 patients. Subjects and methods: The study design was a cross-sectional trial based on a questionnaire survey. The questionnaire contained demographic data regarding patient gender, age and level of education. The questionnaire was assessed by a group of dentists' students. We asked 100 patients about oro-nasal manifestations during the COVID period. This was done written by answer a question paper. Results: 100% of patients suffered from complete loss of test, 65% of patients suffered from severe ulceration. 32.6 % patients suffered from glossitis. 43.5% of patients suffered from gingivitis. Also 82.6% of patients expressed halitosis. 87% of patients suffered from complete loss of smell however, 87 % of patients suffered from headache. 82.6 % of patients suffered from nasal congestion and finally, 21.7 % of patients expressed rhinorrhea. Conclusions: It was proven that mild-to-moderate cases of COVID-19 infection were associated with oro-nasal manifestations, with variable incidence. The most frequent oral manifestation was complete loss of taste, while the least expressed symptom was halitosis. The most frequent nasal manifestations were complete loss of smell and headache, while the least expressed symptom was rhinorrhea.