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280133

Synthesis, Molecular Modeling and Anticancer Activity of New Rescinnamine Derivatives as MMR-Inducers

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Drug discovery and development

Abstract

Mis-match repair proteins (MMR), such as MSH2/MSH6 have DNA dual functions, repair and death functions. Rawolfia alkaloids such as rescinnamine is capable to induce their death conformation lead the cancer cell to the apoptotic pathway.. Cell viability assays were performed using the MTS assay on both deficient and proficient endometrial HEC59 cancer cell line. Additionally, The survival effect of 2-5, 8-10 and 14 vs rescinnamine on PC3-cancer cell line was measured by MTS assay. In this study, rescinnamine analouges 4,5,8-10 and 14 were designed as new MSH2/MSH6 inducers based on virtual fragment screening performed in the advanced Autodock4 program generating 3D pdbq files. The modeling study revealed that most of the synthesized rescinnamine derivatives show small Ki except those two analogues 1 and 3. Results show that most of reserpate intermediate and their rescinnamineanalouges exhibited a promising activity as significant cytotoxic compounds but with small MSH2 dependence that may be considered potential candidate compounds for tumour treatment.

DOI

10.21608/odr.2023.171707.1019

Keywords

Rescinnamine, MMR, Heck, Anticancer, docking

Authors

First Name

shimaa

Last Name

naguib

MiddleName

-

Affiliation

Département of medicinal chemistry, faculty of pharmacy, Minia university, Minia, Egypt.

Email

shimaanaguib_80@mu.edu.eg

City

-

Orcid

-

First Name

Omar

Last Name

Aly

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University , Minia , Egypt

Email

omarsokkar@yahoo.com

City

-

Orcid

0000-0001-9299-920X

First Name

Gamal

Last Name

Abourhma

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University , Minia , Egypt Department of organic Chemistry, Faculty of Pharmacy, Deraya University , Minia , Egypt

Email

gamalaburahma@yahoo.com

City

-

Orcid

-

First Name

Stephen

Last Name

King

MiddleName

-

Affiliation

Department of Chemistry, Wake Forest University, Winston-Salem, NC, USA

Email

kingsb@wfu.edu

City

-

Orcid

-

First Name

Freddie

Last Name

Salsbury

MiddleName

-

Affiliation

Department of Physics, Wake Forest University, Winston-Salem, NC, USA

Email

salsbufr@wfu.edu

City

-

Orcid

-

First Name

Karin

Last Name

Scarpinato

MiddleName

-

Affiliation

Department of Biology, Georgia Southern University, Statesboro, GA,USA

Email

kscarpinato@georgiasouthern.edu

City

-

Orcid

-

First Name

Andrew

Last Name

Diamanduros

MiddleName

-

Affiliation

Department of Biology, Georgia Southern University, Statesboro, GA

Email

adiamanduros@georgiasouthern.edu

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

39075

Issue Date

2023-01-01

Receive Date

2022-10-30

Publish Date

2023-01-01

Page Start

21

Page End

35

Print ISSN

2812-6351

Online ISSN

2812-636X

Article File

ODR_Volume 2_Issue 1_Pages 21-35.pdf

PDF . 661.9kB

Link

https://odr.journals.ekb.eg/article_280133.html

Detail API

https://odr.journals.ekb.eg/service?article_code=280133

Order

280,133

Type

Research Articles

Type Code

2,485

Publication Type

Journal

Publication Title

Octahedron Drug Research

Publication Link

https://odr.journals.ekb.eg/

MainTitle

Synthesis, Molecular Modeling and Anticancer Activity of New Rescinnamine Derivatives as MMR-Inducers

Details

Type

Article

Created At

23 Jan 2023