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257291

Combretastatin A-4 analogs: Past, present, and future directions

Article

Last updated: 29 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Drug discovery and development

Abstract

Microtubules are protein biopolymers created by polymerizing heterodimers of α and β-tubulins. Microtubule disruption induces G2/M cell cycle arrest and abnormal mitotic spindle formation. Microtubules are vital for cell division; without them, cell division cannot occur. Chemotherapeutic interference with tubulin/microtubule polymerization dynamics . Their significance in cell division makes microtubules an appealing target for anticancer drug discovery. Several naturally occurring compounds, such as vinblastine, paclitaxel, combretastatin, and colchicine exert their activity by changing tubulin dynamics, such as polymerization and depolymerization. Tubulin, an essential tumor therapy target, is one of the hotspots in the area of antineoplastic drugs, and it is of a significance importance to design novel inhibitors for this target. Both natural and synthetic scaffolds are the main tubulin inhibitors sources. In this article, the main structural features and motifs tubulin polymerization inhibitors are reviewed. Thus, it provides a theoretical basis for target optimization of new inhibitors of tubulin polymerization.

DOI

10.21608/odr.2022.156180.1008

Keywords

Tubulin polymerization inhibitors, Combretastatin A-4, Anticancer agents, Heterocyclic compounds

Authors

First Name

Muhamad

Last Name

Mustafa

MiddleName

-

Affiliation

IBMM, Univ. Montpellier, CNRS, ENSCM, Montpellier, France

Email

muhamad-mustafa.hussein@umontpellier.fr

City

Montpellier

Orcid

0000-0002-1384-7556

First Name

Yaser

Last Name

A. Mostafa

MiddleName

-

Affiliation

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Email

yaser_22a@hotmail.com

City

-

Orcid

-

First Name

Atef

Last Name

E. Abd Elbaky

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Pharmacy, Port Said University

Email

atef.ebrahim@pharm.psu.edu.eg

City

-

Orcid

-

First Name

Mahmoud

Last Name

Mohamed

MiddleName

-

Affiliation

Pharmacognosy Department, College of Clinical Pharmacy, Albaha University, Saudi Arabia

Email

m_hamed2000@yahoo.com

City

-

Orcid

-

First Name

Dalia

Last Name

Abdelhamid

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

das184@yahoo.com

City

-

Orcid

-

First Name

ElShimaa

Last Name

M. N. Abdelhafez

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

shimaanaguib_80@yahoo.com

City

-

Orcid

-

First Name

Omar

Last Name

Aly

MiddleName

M.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University

Email

omarsokkar@pharm.psu.edu.eg

City

Port Said

Orcid

0000-0001-9299-920X

Volume

1

Article Issue

1

Related Issue

36747

Issue Date

2022-09-01

Receive Date

2022-08-14

Publish Date

2022-09-01

Page Start

55

Page End

64

Print ISSN

2812-6351

Online ISSN

2812-636X

Article File

ODR_Volume 1_Issue 1_Pages 55-64.pdf

PDF . 849.2kB

Link

https://odr.journals.ekb.eg/article_257291.html

Detail API

https://odr.journals.ekb.eg/service?article_code=257291

Order

6

Type

Review Articles

Type Code

2,486

Publication Type

Journal

Publication Title

Octahedron Drug Research

Publication Link

https://odr.journals.ekb.eg/

MainTitle

Combretastatin A-4 analogs: Past, present, and future directions

Details

Type

Article

Created At

23 Jan 2023