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257098

Nitric oxide: Synthesis, Pathophysiology and Application on Oncology and Cardiovascular Diseases

Article

Last updated: 29 Dec 2024

Subjects

-

Tags

Drug discovery and development

Abstract

Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in various physiological as well as pathological processes. Over past decades, NO has emerged as a molecule of interest in carcinogenesis and tumor growth progression. On the other hand, it is also emerging as a potential anti-oncogenic agent. Strategies for manipulating in vivo production and exogenous delivery of this molecule for therapeutic gain are being investigated. However, further validation and experimental/clinical trials are required for development of novel strategies based on NO for cancer treatment and prevention. On the other hand, NO mediates multiple physiological and pathophysiological processes in the cardiovascular system. Moreover, pharmacological compounds that release NO have been useful tools for evaluating the pivotal role of NO in cardiovascular physiology and therapeutics. This review discusses the range of actions of NO in cancer, various mechanisms by which NO acts in different cancers such as breast, cervical, gastric,colorectal, and head and neck cancers are addressed. It also offers an insight into the role of NO in managment of cardiovascular diseases.

DOI

10.21608/odr.2022.154048.1001

Keywords

Nitric oxide donors, pathophysiology, breast cancer, Lung Cancer, cardiovascular diseases

Authors

First Name

Mai

Last Name

Mourad

MiddleName

A. E.

Affiliation

Associate professor of medicinal chemistry, Medicinal chemistry department, Faculty of pharmacy, Port Said university

Email

mai.mourad@yahoo.com

City

-

Orcid

0000-0002-9929-3741

First Name

Omar

Last Name

Aly

MiddleName

M.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University

Email

omarsokkar@pharm.psu.edu.eg

City

Port Said

Orcid

0000-0001-9299-920X

First Name

Ahmed

Last Name

Mourad

MiddleName

A. E.

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Port-Said University, Port-Said, Egypt

Email

ahmed.mourad@yahoo.com

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

36747

Issue Date

2022-09-01

Receive Date

2022-08-02

Publish Date

2022-09-01

Page Start

34

Page End

49

Print ISSN

2812-6351

Online ISSN

2812-636X

Link

https://odr.journals.ekb.eg/article_257098.html

Detail API

https://odr.journals.ekb.eg/service?article_code=257098

Order

4

Type

Review Articles

Type Code

2,486

Publication Type

Journal

Publication Title

Octahedron Drug Research

Publication Link

https://odr.journals.ekb.eg/

MainTitle

Nitric oxide: Synthesis, Pathophysiology and Application on Oncology and Cardiovascular Diseases

Details

Type

Article

Created At

23 Jan 2023