Diabetes is a metabolic disorder that share a common underlying feature of hyperglycemia. In addition to hyperglycemia, diabetes is associated with microvascular and macrovascular complications that are the leading causes of morbidity and death in diabetics. Artemisia herba-alba (AHA) is an aromatic plant belongs to the Artemisia genus. The plant known in the traditional medicine for its preventive capacities against several chronic ailments. Forty-five albino adult male rats were randomly divided into 3 groups of 15 animals for each: group 1; control, group 2; STZ induced diabetes, group 3; protective. At the end of the experiment, rats were sacrificed, then we evaluated blood glucose level, serum insulin, α-l-fucosidase (AFU), C-peptide, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total antioxidant capacity (TAC). Liver tissues were evaluated histologically by photomicrographs of liver sections from the three experimental groups using hematoxylin and eosin (H&E). The results of the AHA protective group showed minimal improvement with mild congestion, inflammatory cell infiltrations and some degenerated hepatocytes and the biochemical analysis confirm that. There is a slight improvement in TAC, ALT, AST, C-peptide, and insulin in protective group compared to diabetic group and significant improvement at AFU and α-amylase in protective group compared to diabetic group.