The aim of the study was to evaluate the protective effect of bradykinin potentiating factor extracted from honey bee venom, Apis mellifera on hematological parameters in diabetic rats. Forty adult male albino rats classified into five groups, control group (G1), STZ diabetic group (G2), BPF group (G3), pre-treatment group BPF+STZ (G4) and post-treatment groupSTZ+BPF (G5). After 30 days from treatment, rats were sacrificed and dissected and the blood were collected from heart. In blood samples, RBCs, HGB, HCT, PLTs, MCV, MCH, WBCs and differential leucocyte count were examined. In the study, STZ diabetic group (G2) showed a significant (P<0.05) and highly significant (p<0.001) decrease in all tested haematological parameters except MCV and MCH, which showed non-significant change (P>0.05) compared to control value. These parameters showed improvement in pre- and post- treated groups as compared to diabetic group. In conclusion our results revealed a Protective effect of bradykinin potentiating factor on haematological parameters of diabetic male rats