Background: Chemotherapy-induced nausea and vomiting (CINV) is a frequent adverse reaction that leads to women inactivity, therapy rejection, and a reduction in compliance. Aim: The current study aimed to evaluate ginger supplement`s effect on chemotherapy-induced nausea and vomiting among breast cancer women. Design: Quasi-experimental design. Setting: the current study was conducted at outpatient chemotherapeutic clinics in Ismailia Teaching Oncology Hospital. Sample: 60 women diagnosed with breast cancer were recruited to participate in the current study. Tools: two tools were used to conduct this study. Tool I: included two parts which involved assessment of the demographic data and cancer history. Tool II: Rhodes Inventory of Nausea, Vomiting, and Retching (INVR). Intervention: The studied women received 400 mg ginger tablets three times daily for three days starting 30 minute before chemotherapy administration on the first day of chemotherapy. All studied and control groups received the routine prophylactic antiemetic medications for chemotherapy induced nausea and vomiting (CINV) before chemotherapy session. Results: There was a decrease in nausea severity and number of vomiting and retching in the study group after administration of ginger tablets with highly statistically significant differences as (P <0.001). Conclusion: Studied women who received ginger had a significantly decreased CINV. Recommendations: Endorse the ginger as one of additional adjuvant line of treatment for CINV.