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Effect of Sodium Benzoate on DNA Breakage and Antioxidant Enzymes in Male Rats

Article

Last updated: 29 Dec 2024

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Tags

Genetic Evolution and its impact on the production efficiency of the animal
Studies on Sequence Gene mutations and monitoring the causes of epidemic diseases

Abstract

The present study was carried out to examine the effects of a food preservative sodium benzoate (SB) on DNA and some biochemical parameters. Because there is a controversy concerning the use of food preservatives, especially as they may have a carcinogenic effect. An adult fifteen males Sprague Dawley rats ,were used in the present experiment The rats were randomly divided into three groups, Group I: normal control group, Group II & III: treated groups were received SB at concentration of 2.5% and 4% for four weeks. At the end of the experiment the animals were sacrificed and samples were taken for biochemical analysis and Quantitative measure of DNA.
The aim of this study was to assess the effect of different concentrations of SB on the DNA breakage in liver cells and on some biochemical parameters in male rats. The obtained result showed that, quantitative measure of DNA significantly decreased in the amount of DNA/1g of liver when two concentrations of SB were added as compared with the control group.
Serum biochemical analysis, revealed significant elevation in total protein, albumin, SOD, GPX and AST at both doses 2.5% and 4% comparing to the control group. ALP was increased in 2.5% dose and decreased in 4% dose, ALT was increased in 4% dose. On the other hand, the body weight was significantly decreased in both treated groups as compared to the control group. Liver weight showed a significant increase in2.5% dose and decrease in 4% dose. 

DOI

10.21608/ejceh.2021.233150

Authors

First Name

Noorah Saleh

Last Name

Al-Sowayan

MiddleName

-

Affiliation

Physiology ,Biology Department ,College of Science, Qassim Univ

Email

nsaoiean@qu.edu.sa

City

-

Orcid

-

First Name

Hanan

Last Name

Sobhy

MiddleName

M

Affiliation

Pharmacology ,Biochemistry Dep. AHRI,Egypt

Email

dr.hanan_mss@yahoo.com

City

-

Orcid

-

First Name

Omaima

Last Name

M.Hassan

MiddleName

M.

Affiliation

Physiology,Biochemistry Dep. AHRI,Egypt

Email

-

City

-

Orcid

-

First Name

Reema Mohamed

Last Name

Al-sallali

MiddleName

-

Affiliation

Biology Dep.,College of Science, Qassim Univ

Email

-

City

-

Orcid

-

First Name

Hanan

Last Name

Sultan

MiddleName

A.

Affiliation

Clinical nutrition, Nutrition Dep.,Research Institute of Ophthalmology,Egypt

Email

-

City

-

Orcid

-

Volume

7

Article Issue

1

Related Issue

33437

Issue Date

2021-05-01

Receive Date

2022-04-24

Publish Date

2021-05-01

Page Start

1

Page End

9

Online ISSN

2357-1039

Article File

EJCEH_Volume 7_Issue 1_Pages 1-9.pdf

PDF . 335.7kB

Link

https://ejceh.journals.ekb.eg/article_233150.html

Detail API

https://ejceh.journals.ekb.eg/service?article_code=233150

Order

233,150

Type

Scientific and Research

Type Code

2,340

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry and Environmental Health

Publication Link

https://ejceh.journals.ekb.eg/

MainTitle

Effect of Sodium Benzoate on DNA Breakage and Antioxidant Enzymes in Male Rats

Details

Type

Article

Created At

23 Jan 2023