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238310

Hepato Protective Effect of Dried MUSHROOM against CCL4 Induced Hepato Toxicity in Liver and Cytogenicity Change in Rats

Article

Last updated: 29 Dec 2024

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Animal Nutrition between increasing productivity and Animal Health
Effect of drugs and insecticides on animal health

Abstract

The present study was carried out to elucidate the Hepato protective effect of dried mushroom against carbon tetrachloride (CCl4) induced hepato toxicity in liver and cytogenicity change in rats .A total of thirty adult male albino rats (150-200 g) were used in this study.Rats were divided into 6 groups each of 5 animals .Group one was kept as acontrol –ve and fed on basal ration only, while the two other groups were fed on basal ration mixed with grind dried mushroom at concentration 5 and 10 % for 30 successive days. Other three groups were subcutaneous injected of with CCl4 (0.1 ml/100 g b.wt. for two weeks) to induced liver fibrosis and cytogenicity changes .One of these group was left as a control +ve (subcutaneous injection of CCl4), whereas the other two groups were fed on basal ration mixed with grind dried mushroom at concentration 5 and 10 % for 30 successive days.
 At the end of experimental period blood samples were collected from each rat for biochemical analysis and cytogenicity. Subcutaneous injection of CCl4 caused significant increase in serum levels of AST,ALT,ALP,creatinine,urea, triglyceride,glucose and total cholesterol LDL. Subcutaneous injection of CCl4 caused significantly increased in micronucleated polychromatic erythrocytes (MPCEs) and ratio of polychromatic to normochromatic erythrocytes (PCE / NCC).Feeding on ration mixed with dried mushroom and injected CCl4 caused significant decreases of MPCEs if compared with control +ve group and decrease of AST and ALT when compared with control +ve group and directed toward normal. The result showed that feeding on dried mushroom showed statistical decrease in micro nucleated polychromatic erythrocytes (MPCEs) and significantly increased in normo chromatic erythrocytes (NCE) compared with control –ve group. 

DOI

10.21608/ejceh.2020.238310

Keywords

dried mushroom, cytogenecity, hepato toxicity

Authors

First Name

Hanan

Last Name

Sultan

MiddleName

A.

Affiliation

Research Institute of Ophthalmology(RIO)

Email

-

City

-

Orcid

-

First Name

Hanan

Last Name

Sobhy

MiddleName

M.

Affiliation

Biochem.Toxicol.&Food Deff. Dep. - Animal Health Research Institute

Email

dr.hanan_mss@yahoo.com

City

-

Orcid

-

First Name

Thanaa

Last Name

Elkholy

MiddleName

A.

Affiliation

Nutrition and food science Dep.-Faculty of Home Economics Al –Azhar university

Email

-

City

-

Orcid

-

Volume

6

Article Issue

1

Related Issue

33435

Issue Date

2020-05-01

Receive Date

2022-05-19

Publish Date

2020-05-01

Page Start

23

Page End

35

Online ISSN

2357-1039

Article File

EJCEH_Volume 6_Issue 1_Pages 23-35.pdf

PDF . 439.6kB

Link

https://ejceh.journals.ekb.eg/article_238310.html

Detail API

https://ejceh.journals.ekb.eg/service?article_code=238310

Order

238,310

Type

Scientific and Research

Type Code

2,340

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry and Environmental Health

Publication Link

https://ejceh.journals.ekb.eg/

MainTitle

Hepato Protective Effect of Dried MUSHROOM against CCL4 Induced Hepato Toxicity in Liver and Cytogenicity Change in Rats

Details

Type

Article

Created At

23 Jan 2023