The present study deal with 240 Anguilla Anguilla offspring collected from Lake El Broullus in Egypt and it was conducted to clarify the clinical pictures. Anal divergence from normal to red colouration may used as a diagnostic tool of Anguillicoliasis. Also, prevalence, abundance and intensity of Anguillicola crassus was recorded. trials for treatment of 300 wild infected A. anguilla was with Artemsa vulgarsim and Levamisol HCl (ADWIA Company) . The survivability of the Artemsa vulgarsim treated group at 35 and 75 g size were 92 and 96% respectively and that treated with levamisol HCl group at 35 and 75 g size were 84 and 92% respectively. While, the control group at 35 and 75 g size were 60 and 80% respectively. The prevalence of A. crassus infection in Artemsa vulgarsim treated group at 35 and 75 g size were 30 and 23% respectively and that treated with levamisol HCl group at 35 and 75 g size were 30%. While, the control group at 35 and 75 g size were 70%. In this study, Anguillicoliosis can be safely treated using Artemsa vulgarsim without any side effects. In this study, Anguillicoliosis can be safely treaded using Artemsa vulgarsim than Levamisol HCl.