The present study was designed to investigate the effects of enzyme kemzyme; recently used multienzymes) and anticoccidial drugs salinomycin as feed additives on productive performance, metabolic and some heamatological parameters in broiler chicks. The study was carried out on 200 male one day-old Hubbard chicks. Chicks were assigned into 4 groups (50 chicks / group).1st group was fed on a basal ration for 8 successive weeks and kept as control group , 2nd group was fed on a basal ration mixed with kemzyme at a dose of (100 ppm / kg ration). 3rd group was fed on a basal ration mixed with salinomycin powder at a dose of 100mg / kg ration). 4 th group was fed on a basal ration mixed with kemzyme (100mg / kg ration) and salinomycin (100mg / kg ration). At the end of the experiment, the results showed a significant increase in average body weight, feed efficiency and a significant decrease in feed conservation ration in groups 2 and 4 in comparison to group 1 at p≤ 0.05. Concerning haemostatic parameters, the levels of PT and APTT were significantly lowered. On the other hand, there was an increase in levels of fibrinogen. The serum biochemical results showed a significant increase in the levels of glucose, liver glycogen and T3 in all supplemented groups in comparison to control one at p≤ 0.05. However, there was a reduction in level of TSH in groups supplemented with kenzyme. There was no significant change in the level of T4 all supplemented groups. We concluded that kemzyme alone and/or in combination with salinomycin induced more pronounced effect than salinomycin alone. Supplementation of broilers feed with kemzyme could help poultry producers adapt to the forthcoming European on antibiotic growth promoters and increasing consumer demand for safe affordable food and exploit the growing demand for natural and organic poultry products.