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248061

Cytogenetic and Pathological Studies on The Effect of Gibberellic acid in rabbit

Article

Last updated: 29 Dec 2024

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Tags

Animal Nutrition between increasing productivity and Animal Health

Abstract

This study was designed to clarify the effect of the plant growth hormone, gibberellic acid (GA3) on the cytogenetic and pathological profile of adult male rabbits. Thirty bucks were classified into 3 equal groups; a control and two other treated groups; the first (indirectly exposed group, IEG) was forced to feed on a previously sprayed green fodder (alfalfa) with the recommended dose of GA3, while the second (directly exposed group, DEG) was forced to drink ad libitum on 75 ppm GA3 in water for 30 successive days.
Both exposed groups evoked a significant increase in the total aberrated cells and total chromosomal aberrations of bone marrow cells, however, the most predominated chromosomal aberrations were deletions, ring chromosomes, end to end associations and aneuploidy, in addition to DNA damage using comet test. The second treated group (DEG) showed a significant increase in the percentage of these aberrations not only comparing to the control but also with the first treated group (IEG). Pathological changes in the liver, kidneys, lungs and testes were reported in both treated groups. These changes were severe in the second treated group (DEG).
After one month recovery period, the deviated parameters of the first treated group (IEG) were nearly returned to the normal values, meanwhile, the second treated group (DEG) still revealed significant changes compared to either the control or the first treated group (IEG).
From this study, It could be concluded that GA3 has a genotoxic and cytotoxic effects. These effects were severe in rabbits directly exposed to the hormone (DEG) compared to those fed on sprayed green fodder with its recommended dose (IEG). 

DOI

10.21608/ejceh.2016.248061

Authors

First Name

M.

Last Name

I

MiddleName

Abdou

Affiliation

Biochemistry and Pathology Dept., Animal Health Research Institute, Zagazig Lab

Email

-

City

-

Orcid

-

First Name

Mervat

Last Name

Ayoub

MiddleName

A

Affiliation

Biochemistry and Pathology Dept., Animal Health Research Institute, Zagazig Lab

Email

-

City

-

Orcid

-

First Name

Maha

Last Name

El Aalem

MiddleName

M

Affiliation

Biochemistry and Pathology Dept., Animal Health Research Institute, Zagazig Lab

Email

-

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

33292

Issue Date

2016-11-01

Receive Date

2022-07-05

Publish Date

2016-11-01

Page Start

566

Page End

579

Online ISSN

2357-1039

Article File

EJCEH_Volume 2_Issue 2_Pages 566-579.pdf

PDF . 848.9kB

Link

https://ejceh.journals.ekb.eg/article_248061.html

Detail API

https://ejceh.journals.ekb.eg/service?article_code=248061

Order

248,061

Type

Scientific and Research

Type Code

2,340

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry and Environmental Health

Publication Link

https://ejceh.journals.ekb.eg/

MainTitle

Cytogenetic and Pathological Studies on The Effect of Gibberellic acid in rabbit

Details

Type

Article

Created At

23 Jan 2023