Medicinal plants being an effective source of both traditional and modern medicines. They are genuinely useful for primary health care so that the objective of the present study was to evaluate the effect of Calotropis Procera plant on rabbits coccidiosis. Fresh leaves of C. Procera were collected from Qena Province, and properly cleaned and dried. The powdered leaves were mixed with rabbit ration at ratio of 10 - 20- 50 and 100g / kg rabbit ration. A total of 36 white New-Zealand male rabbits at 8 weeks old were divided into 6 groups each of 6 rabbits. 1st group used as negative control (coccidian free) and fed on ration free of C. Procera, 2nd group used as positive control, naturally infested rabbits with coccidia and fed on ration free of C. Procera, 3rd , 4 th, 5th and 6th groups naturally infested rabbits and fed on pelleted ration contained 10, 20, 50 and 100g of C. Procera / kg ration respectively for 15 days. Clinical signs and post-mortem lesions were recorded all over the 15 days of the experimental period. Fecal samples were collected for detection and counting of Eimeria oocysts. Blood samples were collected for estimation of RBCs count and Hemoglobin concentration and for biochemical parameters. Samples from livers and intestines were collected for histopathological examination at the end of the experiment. Rabbits fed on 10g/kg pelleted ration of C. Procera had an increase in Eimeria oocysts count, so it hasn't effect on Eimeria Sp. as well as it hasn't toxic effect. While rabbits fed on 20g/kg pelleted ration of C. Procera showed reduction in the number of oocysts in faeces as well as it hasn't toxic effect on hematological, biochemical parameters and biological organs so it can be used as a therapeutic agent against rabbit coccidiosis. With regarding to rabbits fed on 50 and 100g/kg pelleted ration of C. Procera there were an increase in the number of Eimeria oocysts in faeces as a result of off food of rabbits due to the bitter taste of the plant and the toxicity of these doses on rabbits so that high doses cannot be used as anticoccidial agent. Finally, the normal values of hematological, biochemical parameters and disappearance of tissue alterations in the intestine and liver of rabbits infested with coccidian in histopathological examination after feeding of 20g/kg pelleted ration of Calotropis Procera suggest that this plant is safe and have a potential anticoccidial effect at this dose.