This study was conducted to evaluate the efficacy of turmeric powder (Curcuma longa) at a dose of 80 mg/kg ration ,ginger (Zingiber officinale) at a dose of 0.75gm/kg ration and hydrated sodium calcium aluminosilicate (HSCAS) at a dose of 0.5% to counteract the toxic effects of aflatoxin B1 at dose of 2.5ppm/kg ration in broiler chickens. Hundred sixty chicks of one day age were distributed into 8 groups at 7 day of age. First group kept as control , 2nd group fed ration contain AFB1, 3rd  group received ration contain AFB1+ HSCAS,4th group received ration contain AFB1 + Curcuma longa powder,5th group fed ration contain AFB1+ Zingiber officinale, 6th group fed ration contain AFB1 + HSCAS + Curcuma longa + Zingiber officinale 7th group fed ration contain AFB1 + Curcuma longa + HSCAS, 8th group fed ration contain AFB1 + Zingiber officinale + HSCAS. The feeding program continued till 45 day of age. Body weight was recorded weekly, serum samples we collected for biochemical studies at the end of experiment while organs (liver, kidney and intestine) were collected for pathological studies at 21 and 45 day of age. The results cleared that chicks of the 2nd group showed significant decrease in body weight while 3rd ,4th ,5th ,6th ,7th ,8th groups showed a significant increase in body weight which appeared clearly at 45 day of age ,5th and 6th groups recorded the highest body weight .Regarding to biochemical parameters, the results revealed that the chicks of group 2 posses the lowest values of serum total protein, albumin, globulin and showed significant increase in liver enzymes AST, ALT and ALP concentration. Also, a significant increase in serum uric acid, urea, creatnine and total cholesterol concentration level .The use of Curcuma longa and/or Zingiber with or without (HSCAS) showed a significant improvement of the values constituent and returned to normal level. In group 2 the liver, kidney and intestine showed necrotic changes. While groups treated with Curcuma longa and/or Ginger showed improvement in histopathological effects of aflatoxin B1 especialy in group (6) at 45day of age.