The present study was done to illustrate the antioxidant effect of garlic powder on rats' received different doses of CRCl3. Male rats' n=60 were divided to 6 groups each of 10 rats. The 1st group kept as control. The other groups received Crcl3 dissolved in drinking H2O (1mg/l and 10mg/l) and garlic powder 5% mixed with diet as follows. 2 nd group (Crcl3 1mg/l), 3rd group (Crcl31mg/l + 5% garlic powder), 4th group (Crcl3 10 mg/l), 5th group (Crcl310 mg/l + 5% garlic powder) and 6th group (5% garlic powder). After 45 days rats were scarified for analysis of serum and tissue (liver and kidneys) antioxidant enzymes (GPx, SOD and MDA) and minerals (Cu, Zn and Fe). Results showed marked elevation of GPx and SOD in groups received Crcl3 and garlic powder with decrease in MDA level in serum and tissue. Cu and Zn levels were increased in serum and liver tissue of most treated groups while Fe level was marked decreased in serum and tissue of most treated group. From our results we conclude that Crcl3 and garlic has cooperative effect enhancing the antioxidant system and decreasing lipid peroxidation of rats. This may play an important role on improving the body health, competing free radicals that may result from exposure to envirmental pollutants which harm human and animals health.