Beta
ManageSearchChatDiscover
233105

Cytogenetic, Fertility and Pathological Studies Organophosphorus Insecticide of (Profenofose) on Male Rats.

Article

Last updated: 29 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Effect of drugs and insecticides on animal health

Abstract

Oral administration of profenofose for 65 days in a dose of 1/10 and 1/100 LD50, respectively, significantly increase in the percentage of micronucleated polychromatic erythrocytes (MPCE), ratio of polychromatic erythroctes to normal chromatic erythrocytes (PCE/NCE). The PCE/NCE ratio used as a measure for red blood cell proliferation which gave a sign of toxicity or damage of some organs of the body. Also, a significant decrease in weight of testis than the control except at high dose which cause an increase in testis weigh. Although accessory glands (S.V., prostate and epididymis) showed variationi in weights than the control group. The sperm concentration and percentage of motility were decreased, although sperm abnormalities was increased which characterized by coiled tail and headless. The tested pesticide significantly increased the activities of serum AST, ALT and AP and the level of cholesterol, testosterone, bilirubin, while total protein, testosterone and creatinine significantly decreased.The treated rats with profenofos showed congestion, haemorrhage focal area of necrosis and lymphocytic mononuclear cell infiltration in liver and kidney. The spleen was hyperplastic with degeneration of thewall of some blood vessels. Severe degeneration and necrosis of the spermatic cells of the semineferous tubules in testis. Histopathological changes in different organs appeared to be dose dependent, with damage increase in the high doses. 

DOI

10.21608/ejceh.2015.233105

Authors

First Name

Safaa

Last Name

Abo El-Soud

MiddleName

M.

Affiliation

Chemistry Department, Animal Health Research Institute,

Email

-

City

-

Orcid

-

First Name

Seham

Last Name

El-Hadad

MiddleName

F.

Affiliation

Chemistry Department, Animal Health Research Institute

Email

-

City

-

Orcid

-

First Name

Faten

Last Name

El-Said

MiddleName

G.

Affiliation

Chemistry Department, Animal Health Research Institute

Email

-

City

-

Orcid

-

First Name

Samera

Last Name

Sanousi

MiddleName

A.

Affiliation

Chemistry Department, Animal Health Research Institute, Dokki

Email

-

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

33121

Issue Date

2015-11-01

Receive Date

2022-04-24

Publish Date

2015-11-01

Page Start

303

Page End

314

Online ISSN

2357-1039

Article File

EJCEH_Volume 1_Issue 1_Pages 303-314.pdf

PDF . 1.3MB

Link

https://ejceh.journals.ekb.eg/article_233105.html

Detail API

https://ejceh.journals.ekb.eg/service?article_code=233105

Order

233,105

Type

Scientific and Research

Type Code

2,340

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry and Environmental Health

Publication Link

https://ejceh.journals.ekb.eg/

MainTitle

Cytogenetic, Fertility and Pathological Studies Organophosphorus Insecticide of (Profenofose) on Male Rats.

Details

Type

Article

Created At

23 Jan 2023