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233102

Experimental studies on whole bee venom inactivated Rift Valley fever vaccine candidate in vitro

Article

Last updated: 29 Dec 2024

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Tags

Effect of drugs and insecticides on animal health

Abstract

In regard to the safety concerns about RVF vaccines, this work aim to use the safest natural product to inactivate the Rift Valley fever virus (RVFV). Also, our study on the effect of honeybee (Apis mellifera L) venom on some types of cell lines cultures showed it cause apoptosis at lower concentrations and digestion of the cells at relatively higher concentration. In this study, honey bee venom is used as inactivant of Rift Valley fever virus (RVFV). Beside in vitro study on this inactivated RVFV it was injected in rabbits and mice to investigate its behavior in vivo. The results showed that rabbits and mice immunized with this RVFV inactivated vaccine exhibited satisfied antibodies response. Pathological investigation of the immunized mice showed that bee venom inactivated RVF vaccine didn't cause any side effects in liver, kidneys, brain and spleen. Therefore, honey bee (Apis mellifera) venom as a natural product can be used as RVFV inactivant and recommended for animal's vaccines. 

DOI

10.21608/ejceh.2015.233102

Authors

First Name

Samia

Last Name

Kamal

MiddleName

Ahmed

Affiliation

Animal Health Research Institute (AHRI), Egypt

Email

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City

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Orcid

-

First Name

Haggag

Last Name

Bedair

MiddleName

E.

Affiliation

Plant Protection Institute, (ARC)

Email

-

City

-

Orcid

-

First Name

Ragaa

Last Name

Faisa

MiddleName

ASR

Affiliation

Animal Health Research Institute (AHRI), Egypt

Email

-

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

33121

Issue Date

2015-11-01

Receive Date

2022-04-24

Publish Date

2015-11-01

Page Start

274

Page End

290

Online ISSN

2357-1039

Article File

EJCEH_Volume 1_Issue 1_Pages 274-290.pdf

PDF . 722.6kB

Link

https://ejceh.journals.ekb.eg/article_233102.html

Detail API

https://ejceh.journals.ekb.eg/service?article_code=233102

Order

233,102

Type

Scientific and Research

Type Code

2,340

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry and Environmental Health

Publication Link

https://ejceh.journals.ekb.eg/

MainTitle

Experimental studies on whole bee venom inactivated Rift Valley fever vaccine candidate in vitro

Details

Type

Article

Created At

23 Jan 2023