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232184

Protective effect of some antioxidant compound on albino rats intoxicated with aflatoxin

Article

Last updated: 29 Dec 2024

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Tags

Pharmacological and toxicological studies on animal health

Abstract

Mycotoxins are unavoidable contaminants of animal and human feed and food respectively. This study was aimed to investigate the effect of Vitamin E, Vitamin C and Selenium Supplementation to drink water against aflatoxins B1 on the various serum parameters , liver tissue antioxidant and the associated pathological changes. Thirty five male albino rats weighing 120-150 g were used in the present study. Group1 (G1): rats served as control , Group2 (G2) orally administrated aflatoxin B1 dissolved in propylene glycol per Os as a dose of 50µg/kg body weight /week, for 10 weeks . Group3-7 : administrated with aflatoxin B1 50µg/rat/week for 10 weeks . These groups were treated as Group3 (G3):was supplemented with selenium (as sodium selenite was used as 4mg/l). Group4 (G4):was supplemented with vitamin E as 1000mg/l. Group5 (G5):was supplemented with vitamin E plus selenium. Group6 (G6): was supplemented with vitamin C as 1000mg/l. Group7 (G7):was supplemented with vitamin C plus selenium. The results showed significant elevation in the liver and kidney functions, alpha globulin and beta globulin and decrease in concentrations of serum total protein, albumin, and gamma globulin together with A/G ratio. Lipid peroxidase as MDA levels were shown after AFB1 treatment. pathological changes of liver in aflatoxicated rats was discussed briefly. It can be concluded that the hepatotoxicity induced by aflatoxin B1 seemed to be modulated effectively by the simultaneous use of antioxidants: vitamin E or C alone or incombination, with selenium. Moreover, they are more efficient modulating the biochemical alteration , liver antioxidant enzymatic system and pathological changes.

DOI

10.21608/ejceh.2015.232184

Authors

First Name

Mogda

Last Name

Mansour

MiddleName

K

Affiliation

Departments of Biochemistry, Animal Health Research Institute, DokkiGiza; Veterinary Laboratory, Tanta, El-gharbia Governorate, Egypt

Email

-

City

-

Orcid

-

First Name

Amany

Last Name

Y

MiddleName

-

Affiliation

Departments of Biochemistry, Animal Health Research Institute, DokkiGiza; Veterinary Laboratory, Tanta, El-gharbia Governorate, Egypt

Email

-

City

-

Orcid

-

First Name

Nahed

Last Name

El-Mokhtar

MiddleName

M

Affiliation

Departments of Mycology, Animal Health Research Institute, DokkiGiza; Veterinary Laboratory, Tanta, El-gharbia Governorate, Egypt

Email

-

City

-

Orcid

-

First Name

Seham

Last Name

ElHadad

MiddleName

F

Affiliation

Departments of Pathology, Animal Health Research Institute, DokkiGiza; Veterinary Laboratory, Tanta, El-gharbia Governorate, Egypt.

Email

-

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

33121

Issue Date

2015-11-01

Receive Date

2022-04-20

Publish Date

2015-11-01

Page Start

79

Page End

93

Online ISSN

2357-1039

Article File

EJCEH_Volume 1_Issue 1_Pages 79-93.pdf

PDF . 753.6kB

Link

https://ejceh.journals.ekb.eg/article_232184.html

Detail API

https://ejceh.journals.ekb.eg/service?article_code=232184

Order

232,184

Type

Scientific and Research

Type Code

2,340

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry and Environmental Health

Publication Link

https://ejceh.journals.ekb.eg/

MainTitle

Protective effect of some antioxidant compound on albino rats intoxicated with aflatoxin

Details

Type

Article

Created At

23 Jan 2023