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232177

Comparative study between steroidal and non- steroidal compound in rats

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Last updated: 29 Dec 2024

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Abstract

Comparative effects of non steroidal (Ibuprofen) and steroidal (dexamethazon) compound in rats were studied. A total of 60 male albino rats, about 130_150 grams were used and classified into 3 groups. The 1st.group injected distilled water intramuscularly and left as a control. The 2nd and 3rdgroup were injected Ibuprofen and dexamethazon at a dose of 0.9 mg and 0.8 mg/100gm b. wt. intramuscularly respectively for 5 consecutive days. The samples were taken after 1,7,15 and 45 days after stopping injection.
The results revealed that, ibuprofen and dexamethasone induced significant decrease in haemoglobin, red blood cells, total leucocytic count and lymphocytes beside total protein, albumin and globulin. On the other hand, significant increase neutrophil, ALT, AST,ALP, urea , creatinine, total lipid, cholesterol ,triglyceride A/G ratio, glucose and liver glycogen in tissue.
Our results indicated that Ibuprofen and dexamethazon caused dysfunction in blood picture, liver and kidney functions in rats. The study was showing the pathogenesis of Ibuprofen or dexamethazon which could be poisonous in therapeutic doses in rodents. 

DOI

10.21608/ejceh.2015.232177

Keywords

blood picture, Lipid profile, biochemical parameters, steroidal drug, non steroidal drug, Rats

Authors

First Name

Maha

Last Name

Elkholy

MiddleName

M

Affiliation

Animal Health Research Institute, Chemistry Dept., Agric. Res.Center, Giza Egypt

Email

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Orcid

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First Name

G

Last Name

Ibrahim

MiddleName

M

Affiliation

Planing general manager in Kahira Pharmaceutical Company

Email

-

City

-

Orcid

-

First Name

K

Last Name

Deeb

MiddleName

A

Affiliation

Animal Health Research Institute El-Mansoura

Email

-

City

-

Orcid

-

First Name

Ola

Last Name

Talkhan

MiddleName

F.A

Affiliation

Animal Health Research Institute, Chemistry Dept., Agric. Res.Center, Giza Egypt

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-

City

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Orcid

-

Volume

1

Article Issue

1

Related Issue

33121

Issue Date

2015-11-01

Receive Date

2022-04-20

Publish Date

2015-11-01

Page Start

64

Page End

78

Online ISSN

2357-1039

Article File

EJCEH_Volume 1_Issue 1_Pages 64-78.pdf

PDF . 466.8kB

Link

https://ejceh.journals.ekb.eg/article_232177.html

Detail API

https://ejceh.journals.ekb.eg/service?article_code=232177

Order

232,177

Type

Scientific and Research

Type Code

2,340

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry and Environmental Health

Publication Link

https://ejceh.journals.ekb.eg/

MainTitle

Comparative study between steroidal and non- steroidal compound in rats

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Article

Created At

23 Jan 2023