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231368

Hepatoprotective effect of fennel and tiger nut on biochemical parameters and DNA damage in rats

Article

Last updated: 29 Dec 2024

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Tags

Animal Nutrition between increasing productivity and Animal Health

Abstract

 The present study was carried out to investigate studies of dried fennel and tiger nut in
normal and on carbon tetrachloride (CCl4) induced DNA damage using one concentration
of each plants alone for 30 days in male albino rats.
A total of thirty male albino rats (150-200 g) were used in this study.Rats were divided
into 6 groups each of 5 animals. Group one was kept as a control –ve and fed on basal diet
only, while the two other groups were fed on basal diet mixed with grind dried fennel and
tiger nut at concentration (5 g / 100 g diet) for 30 successive days. Other three groups were
subcutaneous injected of CCl4 (0.1 ml/100 g b.wt. for two weeks) to induced DNA damage
change .One of these group was left as a control +ve (subcutaneous injection of CCl4),
where the other two groups were fed on basal diet mixed with grind dried fennel and tiger
nut at concentration (5 g / 100 g diet) for 30 successive days.
At the end of experimental period, blood samples were collected from each rat for
biochemical analysis and rats were then sacrificed to elucidate DNA damage in
hepatocytes.Subcutaneous injection of CCl4 caused significant increase in serum levels of
AST,ALT,ALP,creatinine,urea, triglyceride,glucose,total cholesterol,LDL and lipid
peroxide (MDA) while the levels of serum total protein, albumin ,globulin , A : G ratio and
glutathione transferase (GST) were significantly decreased .The smear on agarose gel had
been observed in CCl4 treated groups indicating random DNA fragmentation and a
hallmark of necrosis . Fennel and tiger nut significantly restored the serum levels of
biochemical parameters directed toward normal as compared with the control +ve group
(injected with CCl4 ). 

DOI

10.21608/ejceh.2015.231368

Keywords

biochemical, nutrition

Authors

First Name

Hanan

Last Name

Sobhy

MiddleName

M

Affiliation

Biochem .Toxicol. &Feed Deff. Dep. - Animal Health Research Institute

Email

dr.hanan_mss@yahoo.com

City

-

Orcid

-

First Name

Sohair

Last Name

Ahmad

MiddleName

S

Affiliation

Nutrition &food science Dep.- Faculty of Home Economics Al –Azhar

Email

-

City

-

Orcid

-

First Name

Hanan

Last Name

Azoz

MiddleName

A

Affiliation

Biochem .Toxicol. &Feed Deff. Dep. - Animal Health Research Institute

Email

-

City

-

Orcid

-

First Name

Areej

Last Name

Yassin

MiddleName

A

Affiliation

Nutrition &food science Dep.- Faculty of Home Economics Al –Azhar

Email

-

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

33121

Issue Date

2015-11-01

Receive Date

2022-04-17

Publish Date

2015-11-01

Page Start

18

Page End

37

Online ISSN

2357-1039

Article File

EJCEH_Volume 1_Issue 1_Pages 18-37.pdf

PDF . 518.3kB

Link

https://ejceh.journals.ekb.eg/article_231368.html

Detail API

https://ejceh.journals.ekb.eg/service?article_code=231368

Order

231,368

Type

Scientific and Research

Type Code

2,340

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry and Environmental Health

Publication Link

https://ejceh.journals.ekb.eg/

MainTitle

Hepatoprotective effect of fennel and tiger nut on biochemical parameters and DNA damage in rats

Details

Type

Article

Created At

23 Jan 2023