A healthy human environment comes from indoors, so Indoor environment quality has a great impact on human health. Time spent in buildings has a direct impact on health and productivity, architects should take action before designing our buildings by using new technologies having the ability to save human health, nanotechnology plays an important role to create healthy buildings and changes the architecture from solid to transparency. This paper will present Factors of Indoor environment quality, nanotechnology and its effect on architecture, The benefits of nanotechnology in air pollution control, The benefits of transparent Materials with nanotechnology to achieve the optimal Indoor environment quality, The WELL Building Standard that is focused exclusively on occupant health. Then the paper will present Examples of international buildings got on WELL certificate, finally the application of Building that applies Fitwell standard by using nano technology (low -E glass).