Due to sad historical events in last few years, structural integrity evaluation for structures damaged by explosions has become an interesting topic for the research community. Blasts may lead to unbalanced or even total collapse of buildings. Hence, accurately representing this action and its results on structures is of high interest. In this paper, a three-dimension (3-d) finite element analysis (FEA) of reinforced concrete (RC) slab subjected to close-in blasts is considered. The dynamic analysis submitted by ABAQUS/Explicit (2014). Abaqus/explicit uses a central difference rule to integrate the equations of motion explicitly through time. The air pressure wave propagation is simulated using built in Conventional Weapon Effect Program (CONWEP). CONWEP generate pressure-time history associated with charge weight in trinitrotoluene (TNT) and stand-off distance. The inelastic behavior of concrete and steel reinforced bars has been represented through concrete damage plasticity (CDP) model and Johnson-cook model, respectively. The obtained results, expressed in terms of maximum displacements, crack pattern and damage index are compared against a set of experimental results carried out from institute of technique physics, college of science, national university of defense technology, Changsha, human, China. A good agreement between the two approaches is observed up to 90%.