Electromagnetic Interference (EMI) and Electromagnetic Compatibility (EMC) are highly contributing to today's modern technology as they refer to the term of handling signal integrity from the point of signal distortion due to the effect of surrounding electromagnetic fields. Our study here aims to control the electromagnetic interference affecting the printed electronic circuit board through layout design. The following study has two major sections, the first one is the software simulation which analysis the signal value through the IC to the PCB regarding the parasitic components would affect the signal shape, then comes the second study as a practical part with data gathering of the signal shape in different EMI mediums. The Subtract of the simulation analysis from the gathered practical data will result the effect of only EMI on the signal. Repeating the previous approach with signal shielding, plane grounding shapes and board shielding will allow us to study and observe each design technique effect on the EMI control process. The proposed study shall affect different sections such as areo-space electronic systems, military electronics, and medical electronic systems, as enhancing the EMC within a PCB shall reflect on signal integrity in these devices enhancing accuracy and reducing electromagnetic noise effect.